The possible role of squalene as a protective agent in sebum.

Studies of sebum. VIII. Observations on the squalene and cholesterol content and the possible functions of squalene in human sebum.

The object of our investigations has been to study the composition ofsebum and to elucidate its role in maintaining the health of the skin. In a previous paper on the hydrocarbons of sebum (Boughton, Hodgson-Jones, MacKenna, Wheatley & Wormall, 1955) we observed that the squalene content of sebum showed wide variations, both in samples collected from the same subject on different occasions and ...

Studies of sebum. IV. The estimation of squalene in sebum and sebum-like materials.

Acne and smoking.

BACKGROUND.: Post-adolescent acne is an inflammatory disorder, whose cause is unknown. Contrasting data are available on correlation between acne and smoking habit. OBJECTIVES.: To verify the frequency of clinically non-inflammatory (atypical) post-adolescent acne (APAA) among women, a possible correlation with cigarette smoking, possible differences in sebum composition in a group of female sm...

Lipid Mediators in Acne

Multiple factors are involved in acne pathogenesis, and sebum secretion is one of the main ones. The role sebum plays in acne development has not been completely elucidated yet; however, increasing amounts of data seem to confirm the presence of alterations in sebum from acne patients. Altered ratio between saturated and unsaturated fatty acids has been indicated as an important feature to be c...

Sebaceous gland lipids.

The principal activity of mature sebaceous glands is producing and secreting sebum, which is a complex mixture of lipids. Sebum composition is different among species and this difference is probably due to the function that sebum has to absolve. In human sebum there are unique lipids, such as squalene and wax esters not found anywhere else in the body nor among the epidermal surface lipids. Mor...